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Similarly, cisplatin is known to have myelotoxicity, neurotoxicity and nephrotoxicity and it can also cause hemolytic anemia, hearing loss and vomiting 12,13,14

Specifically, factors such as heterogeneity in the tumor microenvironment, variations in metabolic characteristics, gene expression and mutation status, immune system activity, and prior treatments and drug responsiveness may all regulate the efficiency of ferroptosis induction in tumor cells and the therapeutic effects

Thus, the studys objective is to investigate the sex-dependent effects of OCPs and PCBs, using chlordane and PCB126 as model compounds, in the context of fatty liver disease and metabolic disruption in a diet-induced obesity model

This focus on a well-defined, primary ischemic stroke group enhances the specificity and relevance of our findings, differentiating this study from prior research involving heterogeneous or mixed patient populations

A significant portion of these studies exhibit a high or uncertain risk of bias [8, 12], highlighting the exigency for methodologically rigorous investigations to validate the therapeutic potential of ozone therapy [2]

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